Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
Identifieur interne : 001648 ( Main/Exploration ); précédent : 001647; suivant : 001649Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
Auteurs : Isabel Pérez-Castro [Espagne] ; Olga Caama O [Espagne] ; Franco Fernández [Espagne] ; Marcos D. García [Espagne] ; Carmen L Pez [Espagne] ; Erik De Clercq [Belgique]Source :
- Organic & Biomolecular Chemistry [ 1477-0520 ] ; 2007.
English descriptors
- Teeft :
- Alkyne, Antiviral, Aryl alkyne, Benzene, Biological evaluation, Biomol, Calcd, Cdcl3, Chem, Click chemistry, Column chromatography, Cycloaddition, Dabco, Dehydroiodination, Eluent, Eluting, Equiv, Etoac, Exch, Fractions eluting, Herpes simplex virus type, Hoch, Hrms, Hrms calcd, Identical spectroscopic features, Inhibitory activities, Mmax, Mmol, Reaction mixture, Room temperature, Royal society, Target compounds, Triazole, Virtual.
Abstract
The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.
Url:
DOI: 10.1039/b710348d
Affiliations:
- Belgique, Espagne
- Galice, Province du Brabant flamand, Région flamande
- Louvain, Santiago de Compostela
- Katholieke Universiteit Leuven, Université de Saint-Jacques-de-Compostelle
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Le document en format XML
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Chem.</title><idno type="ISSN">1477-0520</idno><idno type="eISSN">1477-0539</idno><imprint><publisher>The Royal Society of Chemistry.</publisher><date type="published" when="2007">2007</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">23</biblScope><biblScope unit="page" from="3805">3805</biblScope><biblScope unit="page" to="3813">3813</biblScope></imprint><idno type="ISSN">1477-0520</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1477-0520</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alkyne</term><term>Antiviral</term><term>Aryl alkyne</term><term>Benzene</term><term>Biological evaluation</term><term>Biomol</term><term>Calcd</term><term>Cdcl3</term><term>Chem</term><term>Click chemistry</term><term>Column chromatography</term><term>Cycloaddition</term><term>Dabco</term><term>Dehydroiodination</term><term>Eluent</term><term>Eluting</term><term>Equiv</term><term>Etoac</term><term>Exch</term><term>Fractions eluting</term><term>Herpes simplex virus type</term><term>Hoch</term><term>Hrms</term><term>Hrms calcd</term><term>Identical spectroscopic features</term><term>Inhibitory activities</term><term>Mmax</term><term>Mmol</term><term>Reaction mixture</term><term>Room temperature</term><term>Royal society</term><term>Target compounds</term><term>Triazole</term><term>Virtual</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Espagne</li></country><region><li>Galice</li><li>Province du Brabant flamand</li><li>Région flamande</li></region><settlement><li>Louvain</li><li>Santiago de Compostela</li></settlement><orgName><li>Katholieke Universiteit Leuven</li><li>Université de Saint-Jacques-de-Compostelle</li></orgName></list><tree><country name="Espagne"><region name="Galice"><name sortKey="Perez Castro, Isabel" sort="Perez Castro, Isabel" uniqKey="Perez Castro I" first="Isabel" last="Pérez-Castro">Isabel Pérez-Castro</name></region><name sortKey="Caama O, Olga" sort="Caama O, Olga" uniqKey="Caama O O" first="Olga" last="Caama O">Olga Caama O</name><name sortKey="Caama O, Olga" sort="Caama O, Olga" uniqKey="Caama O O" first="Olga" last="Caama O">Olga Caama O</name><name sortKey="Fernandez, Franco" sort="Fernandez, Franco" uniqKey="Fernandez F" first="Franco" last="Fernández">Franco Fernández</name><name sortKey="Fernandez, Franco" sort="Fernandez, Franco" uniqKey="Fernandez F" first="Franco" last="Fernández">Franco Fernández</name><name sortKey="Garcia, Marcos D" sort="Garcia, Marcos D" uniqKey="Garcia M" first="Marcos D." last="García">Marcos D. García</name><name sortKey="L Pez, Carmen" sort="L Pez, Carmen" uniqKey="L Pez C" first="Carmen" last="L Pez">Carmen L Pez</name><name sortKey="L Pez, Carmen" sort="L Pez, Carmen" uniqKey="L Pez C" first="Carmen" last="L Pez">Carmen L Pez</name><name sortKey="Perez Castro, Isabel" sort="Perez Castro, Isabel" uniqKey="Perez Castro I" first="Isabel" last="Pérez-Castro">Isabel Pérez-Castro</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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